How is amyloid cleared from blood vessels in the brain?
Prof Roxana Carare
University of Southampton
14 February 2020 - 13 February 2021
Full project name:
Adrenergic and cholinergic receptors of the blood vessels as key players in Alzheimer's disease
Researchers at the University of Southampton are working to understand why amyloid builds up in blood vessels in Alzheimer’s disease.
Amyloid is one of the key proteins involved in Alzheimer’s disease. Scientists know that it builds up in the brain, including in the blood vessels, and causes damage to our cells.
A unique waste disposal system helps to clear amyloid from blood vessels in the brain. Scientists have shown that this waste disposal system does not work as well as we get older or in people with increased risk of developing dementia.
Prof Roxana Carare and collaborators aim to find out exactly what changes in this waste disposal system as we get older that stops amyloid being cleared from blood vessels. The scientists will map the proteins that control this waste disposal system.
The researchers will look at how these proteins change as we age, during Alzheimer’s and when there is a build up of amyloid.
By understanding this waste disposal system works in our brain, the researchers hope they will be able to identify ways to increase the clearance of amyloid from blood vessels and stop the damage it causes.
Help us fund more projects like this one
Dementia is one of the world’s greatest challenges. It steals lives and leaves millions heartbroken. But we can change the future.