The Drug Discovery Alliance is an ambitious £30 million initiative to accelerate dementia drug discovery.

In February 2015, we launched a £30 million Alliance of academic Drug Discovery Institutes – one of the largest coordinated dementia drug discovery efforts in the world. The three Institutes at the Universities of Cambridge, Oxford and University College London will work with the academic research community to identify and validate novel targets for neurodegeneration. Our Chief Scientific Officers seek out approaches previously unexplored by the pharmaceutical industry, to build new drug discovery projects. We encourage dialogue at any stage about potential collaborations; please visit the websites to find out more about how the Alliance will interact with the research community.

Cambridge Drug Discovery Institute

Housed in the heart of the Cambridge Biomedical Campus, the Drug Discovery Institute will build collaborative projects across the University and beyond.

Oxford Drug Discovery Institute

Embedded within The Target Discovery Institute, Nuffield Department of Medicine at the University of Oxford, the Oxford Drug Discovery Institute is uniting collaborative efforts for target identification with sophisticated target development capabilities.

UCL Drug Discovery Institute

Located within the Cruciform Building, in the heart of UCL’s Bloomsbury Campus, the Drug Discovery Institute will draw on a wealth of disease expertise to generate well validated targets and optimised leads.

What do the Drug Discovery Institutes do?

Our Drug Discovery Institutes couple the biological expertise of international collaborators with innovative in-house drug discovery expertise. Each institute houses dedicated biology and chemistry teams to evaluate promising new targets. The Institutes establish assays to screen compound libraries for hits against these targets and improve hits into potent and selective lead compounds. This provides the basis for the next generation of medicines to treat neurodegeneration. Together, our Drug Discovery Institutes are exploring a wide range of disease mechanisms spanning the full spectrum of dementias.

Drug Discovery Institute Infographic

I have a potential drug target, which Institute should I contact?

If you have molecular targets of hypotheses that could lead to new therapeutic approaches for neurodegenerative diseases and would like to learn more about collaborating with the drug discovery alliance, contact to kick-start discussions with all three CSOs, or complete a pro-forma . Alternatively, you can contact our Chief Scientific Officers, Dr John Skidmore at the Cambridge DDI, Dr John Davis at the Oxford DDI and Prof Paul Whiting at the UCL DDI who are keen to engage in informal discussions.



Pilot project grant

The Pilot project scheme is meant for novel research ideas that if successful would lead to a Major project or programme application to Alzheimer’s Research UK or other funding body.

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