Targeting a key protein in Dementia with Lewy bodies and Parkinson’s disease

Prof Jody Mason at the University of Bath will investigate the build-up of alpha-synuclein, a key protein implicated in the development of dementia with Lewy bodies and Parkinson’s disease.

Researching

Causes
Treatments

A build-up of protein called alpha-synuclein inside nerve cells can form toxic clumps called Lewy bodies in Parkinson’s disease and dementia with Lewy bodies. These toxic clumps damage nerve cells but the exact link between the build-up of this protein and loss of nerve cells remains unclear.

In this pioneering project, Prof Jody Mason will identify proteins that could effectively stop the build-up of toxic alpha-synuclein and be developed towards future drugs. Finding treatments that prevent the build-up of alpha-synuclein could be life-changing for people with Parkinson’s and dementia with Lewy bodies. It sits at the heart of Alzheimer’s Research UK’s vision of a world free of the fear, harm and heartbreak of dementia.

A build-up of protein called alpha-synuclein inside nerve cells can form toxic clumps called Lewy bodies in Parkinson’s disease and dementia with Lewy bodies. These toxic clumps damage nerve cells but the exact link between the build-up of this protein and loss of nerve cells remains unclear.

In this pioneering project, Prof Jody Mason will identify proteins that could effectively stop the build-up of toxic alpha-synuclein and be developed towards future drugs. Finding treatments that prevent the build-up of alpha-synuclein could be life-changing for people with Parkinson’s and dementia with Lewy bodies. It sits at the heart of Alzheimer’s Research UK’s vision of a world free of the fear, harm and heartbreak of dementia.

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Awarded to
Prof Jody Mason

Institution
University of Bath

Current Award
£331,761.17

Dates
1 September 2018 - 31 August 2021

Full project name
Downsized Cell-derived Peptides as Potent Inhibitors of aS Toxicity