How does tau spread through the brain?

Researchers are investigating how abnormal tau proteins, a key hallmark of Alzheimer’s, spread through the brain.

Researching

Causes

In Alzheimer’s disease and frontotemporal dementia, tau proteins in the brain start to behave out of character. These changes cause tau to stick together and form damaging tangles inside nerve cells.

Abnormal tau can spread across the brain, passing from cell to cell in a dangerous chain reaction. This happens in a predictable way, but it is unclear how the proteins spread and exactly what effect this has on the brain.

Prof Amrit Mudher and her lab will create a new way to study this process that will help us to understand how the damaging tau protein spreads. This knowledge will help scientists searching for new treatments to slow or stop these diseases.

Help us fund more projects like this one

Dementia is one of the world’s greatest challenges. It steals lives and leaves millions heartbroken. But we can change the future.

Your donation will help power research

Awarded to
Prof Amrit Mudher

Institution
University of Southampton

Current Award
£49,784.99

Dates
1 May 2019 - 29 April 2020

Full project name
Dissecting the mechanisms underpinning propagation of Tau pathology in vivo