Research Projects

How does one small brain structure affect Alzheimer’s progression?

Delphine Boche 2018

Awarded to:
Prof Delphine Boche

Current award:

University of Southampton

1 September 2018 - 31 August 2020

Full project name:

Locus coeruleus: its role in cortical and subcortical inflammation in Alzheimer’s disease






Researchers in Southampton are homing in on a particular area of the brain, the locus coeruleus, to understand the role it plays in the development of Alzheimer’s disease.

Dementia is caused by physical diseases, most commonly Alzheimer’s disease.

One of the key hallmarks of Alzheimer’s is the formation of tau tangles in the brain.

These protein tangles first occur in a small brain structure called the locus coeruleus.

Nerve cells in this area of the brain also start to die in the early stages of the disease.

The locus coeruleus is the main producer of a chemical called noradrenaline that plays a key role in thinking, memory and behaviour.

This chemical also reduces inflammation.

Though inflammation is part of the normal immune system response to infection or damage, too much of it in the brain it can do more harm than good and damage healthy nerve cells.

Prof Delphine Boche is using human brain tissue to find out if the early loss of brain cells in the locus coeruleus increases inflammation in the rest of the brain.

If the loss of noradrenaline is linked to increased inflammation, this could be an exciting avenue for the development of life-changing new treatments.

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Dementia is one of the world’s greatest challenges. It steals lives and leaves millions heartbroken. But we can change the future.