Research Projects

How do risk factors interact to impact Alzheimer’s disease progression?

Awarded to:
Prof Frances Edwards

Current award:

University College London

1 March 2020 - 28 February 2023

Full project name:

Effects of Alzheimer’s disease risk factors on gene expression, pathology and synaptic transmission in aged Alzheimer’s KI mice.






Aging, our genes and our diet are thought to be major risk factors for the development of Alzheimer’s disease. But little is known about how these factors interact in the disease or how these interactions impact disease progression.

Prof Frances Edwards and collaborators aim to understand how these factors, alone and in combination, affect brain changes that underly Alzheimer’s disease.

The researchers aim to understand if brain cells become less capable of dealing with the things that go wrong in Alzheimer’s disease as we age and whether genetics or our diet exacerbate this aging affect.

This research will allow researchers to build a more in depth understanding of Alzheimer’s as well as identifying new disease pathways and potential targets for future drugs.

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