Alzheimer’s Research UK has funded more than £17.4 million of pioneering research to help advance our understanding of dementia with Lewy bodies.

The research we are funding is looking at the alpha-synuclein protein and other proteins involved in the disease. This is building a clearer picture of why and how these proteins build up and affect the brain.

Our scientists are also working to develop new and innovative ways to detect DLB, and to identify targets for the development of new treatments.

Backed by our passionate scientists and supporters, we’re challenging the way people think about dementia, bringing together the people and organisations who can speed up progress, and investing in research to make breakthroughs possible.

Dementia with Lewy bodies

Information in this booklet is for anyone who wants to know more about dementia with Lewy bodies (DLB). This includes people living with DLB, their carers, families and friends.

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Research projects

Using stem cells and specialised chambers to unravel dementia

Researchers at the University of Manchester are using sophisticated chambers to monitor how toxic proteins spread in dementia and the complex relationship between brain cells and their blood supply.

Alzheimer’s disease / Dementia with Lewy bodies / Early-onset Alzheimer’s disease / Frontotemporal dementia / Posterior cortical atrophy / Primary progressive aphasia / Vascular dementia

Using data from brain donations to investigate the impact of multiple underlying causes of dementia

Use information from the Brains for Dementia Research Programme to find out which disease combinations lead to a more rapid decline of memory and thinking skills.

Alzheimer’s disease / Dementia with Lewy bodies / Early-onset Alzheimer’s disease / Frontotemporal dementia / Vascular dementia

Using brain scans to investigate changes in the brain over time

Prof Nick Fox and Prof Jon Schott are studying brain scans to investigate changes in the brain over time in a longitudinal amyloid-PET/MRI study of the 1946 birth cohort.

Alzheimer’s disease / Dementia with Lewy bodies / Early-onset Alzheimer’s disease / Frontotemporal dementia / Posterior cortical atrophy / Vascular dementia

Treating hearing loss in people at a high risk of dementia

Researchers at the University College London are developing a pilot trial to ensure people with hearing loss and mild cognitive dementia start and continue to use hearing aids. They will follow-up to evaluate its effectiveness in reducing the risk of dementia.

Alzheimer’s disease / Dementia with Lewy bodies / Early-onset Alzheimer’s disease / Frontotemporal dementia / Posterior cortical atrophy / Primary progressive aphasia / Vascular dementia

Targeting a key protein in Dementia with Lewy bodies and Parkinson’s disease

Researcher, Prof Jody Mason at the University of Bath will investigate the build-up of a key protein in the development of dementia with Lewy bodies.

Dementia with Lewy bodies

Looking into head injury and dementia

Research at Imperial College London is exploring the link between head injury and dementia

Alzheimer’s disease / Dementia with Lewy bodies / Frontotemporal dementia / Posterior cortical atrophy / Primary progressive aphasia

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Dementia Research Infoline

Want to know more about current research? Keen to get involved in research projects?

Contact the Dementia Research Infoline,

9am-5pm, Monday to Friday

0300 111 5 111

infoline@alzheimersresearchuk.org