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Posted on 17 Jan

Frailty may predict link between disease and dementia symptoms

Lancet Neurol: Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer’s disease: a cross-sectional analysis of data from the Rush Memory and Aging Project Researchers in the US have found that those who are frailer in later life are more likely to have the diseases underlying dementia and the […]

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Posted on 16 Jan

Physical exercise linked to cognitive health

Researchers in the US have found that older adults who are more physically active in later life have better memory and thinking skills. They also found that this association was not affected by having Alzheimer’s or signs of other neurodegenerative diseases. The results are published Wednesday 16 January in the medical journal, Neurology. The researchers […]

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Posted on 14 Jan

Leaky blood vessels could be key to diagnosing memory and thinking problems

Researchers in the US have found key biological markers relating to the breakdown of the blood-brain barrier are associated with thinking problems and occur independently to changes in the hallmark Alzheimer’s protein’s amyloid and tau. The results are published today (Monday 14 January) in the scientific journal Nature Medicine. Researchers at the University of Southern […]

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Posted on 09 Jan

BMI and waist-to-hip ratio link to brain health

Neurology: Association of body mass index and waist-to-hip ratio with brain structure Researchers from Loughborough University and University College London have identified a link between body mass index (BMI), waist-to-hip ratio (WHR) and the structure of the brain. The study, published today (Wednesday 9 January) in the journal Neurology, found that participants with a higher […]

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Posted on 09 Jan

Wearables measuring sleep could provide Alzheimer’s opportunity

Science Translational Medicine: Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease Scientists in the US have found that people who experience less deep sleep have higher levels of hallmark Alzheimer’s proteins in the brain. The findings are published today (Wednesday 9 January) in the journal, Science Translation Medicine. Researchers […]

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Posted on 08 Jan

Boosting histamine helps memory recall

Biological Psychiatry: Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories Researchers in Japan have investigated the role of histamine in retrieving memories, finding that boosting histamine has some positive effects in both mice and people, helping them to remember objects. The study is published today (8 January) in Biological Psychiatry. Dr David […]

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Posted on 02 Jan

Experimental drug shows promise in Alzheimer’s mice

Cell Reports: Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists Researchers from Yale University in the US have identified an experimental drug that can block a crucial step in the Alzheimer’s disease process, showing it to improve nerve cell connections and memory function in mice with features of the disease. The study […]

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Posted on 19 Dec

Regular exercise improves thinking skills

Neurology:  Lifestyle and neurocognition in older adults with cognitive impairments. A randomized trial Researchers in the US have found that regular aerobic exercise may improve thinking skills in people with cognitive impairment but no dementia. The results are published today (19 December) in the journal Neurology. The researchers looked to see if people who take […]

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Posted on 13 Dec

Further evidence that Alzheimer’s protein amyloid could spread like prions

Nature: Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone Scientists from University College London (UCL) have presented further evidence in mice that the amyloid protein, which builds up in the brain during Alzheimer’s, can be transmitted through contaminated brain tissue extracts in a similar way to the prion protein responsible for Creutzfeldt-Jakob disease […]

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Posted on 12 Dec

New insights link brain injury, depression and PTSD to dementia in women

Neurology: Military- related risk factors in female veterans and risk of dementia Scientists have studied female US military veterans and found that traumatic brain injury (TBI), depression or post-traumatic stress disorder (PTSD) are linked to an increased risk of dementia. The findings are published today (Wednesday 12 December) in the scientific journal, Neurology. The researchers […]

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