This is what hope leads to

Play Video

It’s the breakthrough we’ve all been waiting for. A dementia drug called lecanemab can effectively slow memory loss for people in the earliest stages of Alzheimer’s disease.

But there is more good news to share.

Lecanemab opens a door for many further breakthrough treatments – with drugs that will be more powerful, have fewer side effects and which can benefit millions more people, living with every kind of dementia.

You can help us to develop breakthrough new treatments to change the lives of who we love most


Today, we are asking for you to support our Drug Discovery Alliance, which brings together world-leading dementia scientists from across the UK.

in their sights is a brand-new drug, designed to fix faults in brain cells that cause dementia, which could lead to a new life-changing treatment.

This work builds on decades of dedicated scientific research. But to get it across the finish line, we need you.

So please help our scientists today, as we develop these life-changing drugs.

Whatever you can give will count.

How you are making our hopes for new treatments a reality

Microglia cells play an essential role in removing harmful waste from our brains. Malfunctions in these cells are one of the many biological processes which can be linked to dementia.

Cells to Compounds

Our scientists at our Oxford Drug Discovery Institute have built a virtual model of a specific protein found inside microglial cells and tested prototype compounds, to be sure they are repairing any abnormal, damaging behaviour.

Now, these prototypes are being turned into real-world compounds – to find the one which works best.

This final compound could become the basis of an experimental new dementia treatment that could work in tandem with drugs like lecanemab – extending their benefits to more people or helping them to work in the later stages of Alzheimer’s disease.

Or it could become a drug in its own right. We’ll have to refine it’s design, test in clinical trials to prove it’s effective and safe, and the treatment will need to be affordable and accessible for the people who will benefit from it.

Drugs to treatment

With your help all of this can happen.

Our goal has always been to deliver life-changing treatments for all forms of dementia, just as you would expect to find with other life-changing conditions, such as cancer or heart disease.

It’s what people living with dementia deserve, and it’s all possible thanks to you.

Hear directly from Prof Paul Brennan and our scientists at the forefront of dementia research, and find out more about how your donations support our work in our next Lab Notes event