Genes and dementia
One of the best ways to understand the genetics underlying Alzheimer’s disease is through large studies of epigenetics.
Dr Dervis Salih and researchers at University College London are using short sticky fragments of DNA to measure gene activity in dementia.
Research at the University of Manchester is investigating how an error in a gene called C9ORF72 causes dementia and motor neurone disease.
TREM2, discovered by Dr Rita Guerreiro in 2012, is a gene that codes for a protein produced by microglia – the brain’s immune defence cells.
Scientists at Cardiff University studying the genetics of Alzheimer’s, have discovered 11 new areas of the genome linked to a higher risk of Alzheimer’s.
It often comes as a surprise to people that there’s a link between Down’s syndrome and dementia. But more than 60% of people with Down’s syndrome will develop Alzheimer’s – the most common form of dementia – before the age of 60. With our help, scientists are unravelling why.