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Posted on 30 Jan

Phase III trial for Alzheimer’s drug ended early

Today (Wednesday 30 January), the pharmaceutical company Roche has announced they have ended their phase III clinical trial of the potential Alzheimer’s drug, crenezumab, which was designed to treat people in the early stages of Alzheimer’s disease. The decision to stop the CREAD1 and CREAD2 clinical trials early was based on results that suggested crenezumab […]

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Posted on 30 Jan

Gut bacteria linked to dementia risk

Poster Presentation: American Stroke Association’s International Stroke Conference 2019: Gut Microbiota and Dementia: A Cross-Sectional Study Researchers in Japan have studied the make-up of 128 people’s stool samples finding differences in the type and level of gut bacteria present in people with dementia and those without the condition. The results have been presented in a […]

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Posted on 28 Jan

Intensive blood pressure treatment reduces memory and thinking decline

JAMA: Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial Researchers from the SPRINT MIND study in the US have found that treating high blood pressure reduces the risk of mild cognitive impairment (MCI). The results are published today (Monday 28 January) in the scientific publication JAMA. The new […]

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Posted on 23 Jan

Bacteria behind gum disease linked to Alzheimer’s

Scientific Advances: Porphyomonas gingivalis in Alzheimer’s disease brains: evidence for disease causation and treatment with small-molecule inhibitors Researchers have found Porphyomonas gingivalis, a bacteria linked to gum disease, present in the brains of people with Alzheimer’s disease. The international team of researchers also found that treating mice who have an oral P. gingivalis infection with […]

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Posted on 22 Jan

Chemical changes could be a target for Alzheimer’s disease

Brain: Inhibition of EHMT1/2 Rescues Synaptic and Cognitive Functions for Alzheimer’s Disease Researchers in the US have found that treating reversible chemical changes to the DNA code in mice with features of Alzheimer’s disease can improve their memory. The findings are published today (Tuesday 22 January) in the journal Brain. So-called ‘epigenetic changes’ occur when […]

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Posted on 21 Jan

Blood tests could hold key to early Alzheimer’s diagnosis before memory loss

Nature Medicine: Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s Disease Researchers have developed a test to detect biological signs associated with the early stages of neurodegenerative diseases like Alzheimer’s. The findings are published today (Monday 21 January) in the scientific journal Nature Medicine. The researchers looked at blood samples from people […]

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Posted on 17 Jan

Frailty may predict link between disease and dementia symptoms

Lancet Neurol: Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer’s disease: a cross-sectional analysis of data from the Rush Memory and Aging Project Researchers in the US have found that those who are frailer in later life are more likely to have the diseases underlying dementia and the […]

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Posted on 16 Jan

Physical exercise linked to cognitive health

Researchers in the US have found that older adults who are more physically active in later life have better memory and thinking skills. They also found that this association was not affected by having Alzheimer’s or signs of other neurodegenerative diseases. The results are published Wednesday 16 January in the medical journal, Neurology. The researchers […]

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Posted on 14 Jan

Leaky blood vessels could be key to diagnosing memory and thinking problems

Researchers in the US have found key biological markers relating to the breakdown of the blood-brain barrier are associated with thinking problems and occur independently to changes in the hallmark Alzheimer’s protein’s amyloid and tau. The results are published today (Monday 14 January) in the scientific journal Nature Medicine. Researchers at the University of Southern […]

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Posted on 09 Jan

BMI and waist-to-hip ratio link to brain health

Neurology: Association of body mass index and waist-to-hip ratio with brain structure Researchers from Loughborough University and University College London have identified a link between body mass index (BMI), waist-to-hip ratio (WHR) and the structure of the brain. The study, published today (Wednesday 9 January) in the journal Neurology, found that participants with a higher […]

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