This page aims to give an overview of the range of currently available treatments for dementia.
The information here does not replace the advice that doctors, pharmacists or nurses may provide, but gives you information which we hope you will find helpful.
Drug treatments for dementia
If you have been diagnosed with a form of dementia, there are several drugs that could help. These may differ depending on the type of dementia you have.
You can talk with your doctor about the treatments available and together you can decide which ones might be best for you. You might also like a carer or member of your family to be involved in these decisions.
If you are prescribed a drug for dementia, treatment is usually started by a specialist doctor. Specialist doctors who see people with dementia include psychiatrists, geriatricians and neurologists. Once treatment has been started, it may be continued and monitored either by a specialist or by your GP.
The NHS 111 service can give you advice if you cannot reach your doctor: Telephone: 111 – 24 hours a day.
People with Alzheimer’s disease could benefit from taking a cholinesterase inhibitor. Cholinesterase inhibitors are not a cure, but can treat some symptoms in some people.
There are three cholinesterase inhibitors available to treat Alzheimer’s:
- donepezil (Aricept)
- rivastigmine (Exelon)
- galantamine (Reminyl)
All these drugs work in a similar way. So far, no difference in the effectiveness of the three drugs has been shown, but some people may respond better to one drug than another or have fewer side-effects.
These drugs are licensed and recommended specifically for people with mild to moderate Alzheimer’s. Doctors may continue to prescribe one of these drugs for longer if they believe it is still having a beneficial effect.
These treatments are normally given as tablets or capsules. Donepezil is also available as a tablet that dissolves on the tongue and galantamine can be given in liquid form. Rivastigmine is available in liquid form or in patches, where the drug is absorbed through the skin. Your doctor will discuss the most suitable form for you.
People with Alzheimer’s may find that their condition improves by taking a cholinesterase inhibitor. This could be improvement in thinking, memory, communication or day-to-day activities. Others may find that their condition stays the same, when they would have expected to become less able as the condition develops. Some people may not notice any effect at all.
As these drugs don’t stop the disease from progressing in the brain, symptoms can continue to get worse over time. However, they can help some people to function at a slightly higher level than they would do without the drug.
The most common side-effects of cholinesterase inhibitors are feeling or being sick, diarrhoea, having trouble sleeping, muscle cramps and tiredness. These effects are often mild and usually only temporary. Not everyone will experience side-effects.
In Alzheimer’s disease, nerve cells become damaged and lose their ability to communicate. Cholinesterase inhibitors work by increasing the amount of a chemical called acetylcholine, that helps messages to travel around the brain. These messages are vital to the way we move, think and remember. Cholinesterase inhibitors can reduce the symptoms of Alzheimer’s for a time.
Memantine (Ebixa or Axura) is recommended as an option for people with severe Alzheimer’s disease, and for people with moderate Alzheimer’s if cholinesterase inhibitors don’t help or are not suitable. Memantine is normally given as a tablet, but it is also available as a liquid. Your doctor will discuss the most suitable form for you. Like cholinesterase inhibitors, memantine is not a cure. However, it can help with some symptoms.
Memantine is currently only recommended for people with Alzheimer’s disease. Research is underway to learn more about whether it might be beneficial for people with other forms of dementia.
People with moderate or severe Alzheimer’s disease are sometimes offered combination therapy, where a cholinesterase inhibitor is given in addition to memantine.
Some people taking memantine may not notice any effect at all. Others may find that their condition stays the same, when they would have expected it to decline.
Some people experience side-effects when taking memantine. The most common side-effects of memantine are headaches, dizziness, drowsiness and constipation. These effects are usually only temporary.
Memantine also helps nerve cells in the brain communicate with each other. It does this by helping to rebalance chemical changes in the brain in Alzheimer’s disease. This can help protect brain cells, allowing them to communicate more clearly for longer, and it helps reduce the symptoms of Alzheimer’s disease for a while.
Vascular dementia can occur when blood vessels become damaged and blood flow to the brain is reduced. This type of dementia is linked to risk factors for vascular disease. These include high cholesterol, high blood pressure, type 2 diabetes, stroke and heart problems. People with these conditions have an increased risk of developing vascular dementia.
While there are currently no specific treatments for vascular dementia, a doctor may prescribe medication to treat cardiovascular risk factors like high blood pressure or diabetes. It’s possible that treating these conditions could slow the development of vascular dementia, but more research is needed in this area.
A doctor may also advise taking up a healthier lifestyle by stopping smoking, taking exercise and eating healthily to help control these underlying conditions.
Vascular dementia is sometimes caused by a stroke, so a doctor may also recommend physiotherapy, occupational therapy or speech therapy if appropriate.
Cholinesterase inhibitors are not usually beneficial for people with vascular dementia. However, they may be helpful for people with both Alzheimer’s and vascular dementia, also called ‘mixed dementia’.
Dementia with Lewy bodies (DLB)
Dementia with Lewy bodies is caused by small round clumps of protein that build up inside nerve cells in the brain. One of these proteins is called alpha-synuclein and the clumps it forms are called Lewy bodies. The protein clumps damage the way nerve cells work and communicate. In DLB, the affected areas of the brain control thinking, memory and movement.
There is evidence that cholinesterase inhibitors may help to improve some of the symptoms of DLB, including thinking skills and visual hallucinations. So far memantine has only been shown to have small benefits for people with DLB, but it may be offered to those who can’t be given donepezil or rivastigmine.
Lewy bodies are also responsible for the damage that causes movement problems in Parkinson’s disease. Levodopa, a drug used to treat Parkinson’s, may also be used to treat movement problems in DLB. There is a risk this drug may provoke or worsen visual hallucinations. If this occurs, inform your doctor. Physiotherapy could also help someone with DLB with their movement problems.
Frontotemporal dementia (FTD)
Frontotemporal dementia is a relatively rare form of dementia, accounting for less than 5% of all dementia cases. The disease is caused by damage to cells in areas of the brain called the frontal and temporal lobes. These areas regulate our personality, emotions and behaviour, as well as our speech and understanding of language.
At the moment there are no drugs specifically to treat frontotemporal dementia. Other drugs may help some symptoms of the disease; for example an antidepressant drug may be considered. You can find more details in the next sections.
Physical symptoms such as problems swallowing or moving may need careful management in their own right. Someone with frontotemporal dementia may be offered speech therapy or physiotherapy to help with these symptoms.
Non-drug treatments for dementia
There are several types of cognitive therapy that may benefit people with dementia. Cognitive skills can be described as thinking skills, and cognition is a word used to describe thought processes.
Cognitive stimulation activities are designed to stimulate thinking skills and engage people who have dementia. They are often group-based and include games, with an emphasis on enjoyment. Cognitive stimulation can be provided by health or social care staff with appropriate training.
The benefits of cognitive stimulation for people with dementia could include improvement in memory, thinking skills and quality of life.
Other types of cognitive therapy are currently being tested to see if they can benefit people with dementia. These include reminiscence therapy, where past activities and experiences are discussed, usually with photographs and other familiar objects from the past.
Cognitive rehabilitation is also being tested to find out if it can help people with dementia. This technique aims to improve how people manage everyday tasks by setting personal goals and finding ways to achieve them. The focus is on developing the person’s strengths and helping them to overcome their individual challenges.
It is best to be wary of ‘herbal’, ‘alternative’ or ‘complementary’ products that claim to benefit people with dementia, or to improve memory. There has been very little high-quality research into these products, and some may not be safe for people with dementia. For example, despite anecdotal reports, there is currently very little evidence from studies in people that coconut oil can benefit people with dementia.
The most important thing when considering taking a complementary therapy is to talk to your doctor. Some of these products interact with normal medication, so the doctor needs to know about anything being taken. These products should never be taken as a substitute for prescribed medicines.
Availability of dementia treatments
Cholinesterase inhibitors are currently available across the UK on NHS prescription, and are recommended for people with mild and moderate stage Alzheimer’s disease. Memantine is available on NHS prescription for people in the later stages of Alzheimer’s, and for people with moderate Alzheimer’s if cholinesterase inhibitors don’t help or are not suitable.
People with mild to moderate dementia should have the opportunity to participate in cognitive stimulation if it is available. It should be offered irrespective of any drug prescribed.
Treatments for other symptoms of dementia
In the later stages of dementia, people with the condition may experience other symptoms such as depression, anxiety, agitation and aggression. A doctor may advise a non-drug treatment to help with these symptoms first. Non-drug treatments could include exercise, cognitive therapy or group activities such as singing.
You can discuss your treatment options with your doctor.
Depression is common in all forms of dementia. Your doctor may consider recommending cognitive behavioural therapy (CBT). CBT provides an opportunity for people to talk about their worries and concerns with a specialist practitioner. It aims to help people develop different ways of thinking and behaving.
There may also be other therapies offered in your local area that could help; these might include exercise or group activities such as music therapy.
You may be offered an antidepressant drug, either as an alternative to CBT or in combination with it. There are different types, or classes, of antidepressant; some are not suitable for people with dementia. Your doctor will be able to advise you if an antidepressant could help and which type would be best.
Agitation, anxiety and aggression
Some people with dementia experience agitation, aggression, delusions (negative or mistaken beliefs), severe anxiety, hallucinations, sleep disturbances and other behavioural symptoms.
These symptoms can be difficult for a carer to manage and you might hear them called ‘challenging behaviours’. They are also known as neuropsychiatric symptoms or behavioural and psychological symptoms of dementia (BPSD).
While these symptoms may be difficult to handle, there are simple things that might help. It may be possible to uncover the cause or trigger of aggression or agitation. A person’s physical health could affect their behaviour – they may be constipated or need the toilet. Someone’s surroundings can also affect their behaviour, as well as their feelings towards certain situations.
Finding out if there are triggers that cause aggressive or agitated behaviour means it might be possible to remove, treat or avoid them. Mild behavioural symptoms can often be helped with adjustments to physical surroundings, reassurance or changes to daily routine. Possible triggers could include:
- undetected pain or discomfort
- social situations
- factors in the environment
- disruption to routine.
For advice and support for coping with challenging behaviours and caring for someone with dementia, you can contact one of the organisations listed here. Your doctor or nurse will also be able to offer you advice.
To help someone with agitation, a doctor or healthcare worker may consider offering a non-drug therapy. The type of therapy depends on someone’s preferences, skills and abilities. It also depends on what is available in your local area. These might include:
- therapeutic use of music or dancing
- animal-assisted therapy
- multi-sensory stimulation.
A person’s response to these therapies should be carefully monitored and the approach changed if needed. These therapies can be given by a health or social care worker with appropriate training and supervision.
Some people with dementia may find one of these therapies helpful and there is some research that suggests they may be beneficial. However, the studies done so far have been small so more research is needed.
If non-drug measures have not worked and someone is very distressed they may be offered treatment with an antipsychotic drug.
These drugs should only be offered if there is severe distress or immediate risk of harm to the person themselves or others around them. While they can be helpful in certain circumstances, antipsychotics can also have serious side-effects so other methods should be tried first.
Anyone prescribed an antipsychotic drug should be closely and regularly monitored by a doctor. If you have any concerns about antipsychotics being used you can talk to your doctor.
There are several different antipsychotic drugs. One, called risperidone (Risperdal), is licensed to treat severe agitation, aggression and behavioural changes in people with dementia. Short term treatment can help to reduce these symptoms.
On rare occasions, other antipsychotic drugs may be considered at a low dose if someone is extremely aggressive. Haloperidol (Haldol, Serenace) is another antipsychotic that might be considered for a very short period (one week). Lorazepam (Ativan, Temesta), a type of drug called a benzodiazepine, is not an antipsychotic drug but may also be used in a similar way for a short time to help reduce very aggressive behaviour.
All antipsychotics can have serious side-effects. Long term use of antipsychotic drugs is associated with an increased risk of stroke and may worsen memory and thinking in people with Alzheimer’s disease. For this reason, antipsychotics should not usually be used for longer than three months and the benefits of prescribing them need to be carefully weighed up against the risk of side-effects for each person.
Antipsychotics can be particularly dangerous for people with dementia with Lewy bodies and should only be prescribed in severe circumstances. They can cause symptoms to get worse.
Different antipsychotic drugs have been used in the past to treat dementia symptoms, but they are not recommended or licensed for this. You can, and should, talk with your doctor about what type of medication is being prescribed and why.
This information was updated in April 2018 and is due for review in April 2020. Please contact us if you would like a version with references.