The role of inflammation in Dementia with Lewy Bodies

A Southampton doctor plans to establish his career in research by looking at how the brain’s immune system might play a role in the course of a common cause of dementia.



Dementia with Lewy Bodies (DLB) is associated with problems in memory and thinking as well as hallucinations, changes in alertness and movement difficulties. There is increasing evidence that the brain’s immune response could be an important driving force in Alzheimer’s disease, and Dr Amin wants to investigate whether this process of inflammation may also play a role in DLB. Dr Amin’s Alzheimer’s Research UK Clinical Research Fellowship is supported by funding from the Lewy Body Society.

DLB is the third most common cause of dementia, affecting over 100,000 people in the UK. Dr Amin hopes the findings of this study will improve our understanding of the disease, drive research into new treatments and lead to new ways to detect early changes in the disease in blood.

Dr Jay Amin at the University of Southampton has been awarded £213,317.40 over three years to conduct the research. The Clinical Research Fellowship will allow Dr Amin to develop his career in dementia research, in addition to treating patients as part of his clinical work.

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Jay Amin

Awarded to
Dr Jay Amin

University of Southampton

Current Award

6 August 2014 - 5 August 2017

Full project name
Systemic and central inflammation in Dementia with Lewy Bodies

Scientist Focus: Dr Jay Amin

Kirsty Marais talks to Jay about the aims of his project, how he became interested in dementia research and what interests him outside the clinic.

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