We have a number of resources and guidelines that can help with experimental design.
International Alzheimer’s Disease Research Portfolio
You can use the International Alzheimer’s Disease Research Portfolio (IADRP) online database to visualize and track changes in the Alzheimer’s disease research landscape, identify gaps in critical research areas, explore opportunities for collaboration and avoid duplication in funding. The database is supported by the US National Institute of Aging and the Alzheimer’s Association with the participation of several international funders including Alzheimer’s Research UK. You can also take a look at Alzheimer’s Research UK’s own research portfolio.
Grant writing for Success
We hosted a ‘Grant Writing for Success’ seminar with the British Neuroscience Association, to share insights into funding opportunities from Alzheimer’s Research UK and top tips from Prof David Dexter, who sits on a number of grant review boards. You can watch the videos online here:
Dr Rosa Sancho, Head of Research at Alzheimer’s Research UK: Funding opportunities from Alzheimer’s Research UK
Prof David Dexter, Professor of Neuropharmacology, Imperial College London: How to write a good grant
Brains for Dementia Research
Brains for Dementia Research (BDR) is a joint initiative between Alzheimer’s Research UK and Alzheimer’s Society, in association with the Medical Research Council, which aims to provide high quality human brain tissue to the dementia research community. Not only does BDR provide ‘gold standard’ histopathological samples (including age-matched controls), but each prospective donor takes part in regular, standardised cognitive assessments. As such, donated brain tissue comes which a rich medical history – a unique feature of BDR over other sources of brain tissue.
The scheme is open to researchers in the UK and internationally. BDR can grant ‘generic ethical approval’ to UK based researchers. This will, in most cases, enable studies to proceed without researchers being required to obtain their own ethical approval, although there may be local institution regulations in place. Please visit the Brains for Dementia Research website for more information.
Alzheimer’s Research UK encourages researchers to consider the use of BDR tissue, where appropriate, in their grant applications.
The National Institute of Health Research and the Clinical Research Network
Alzheimer’s Research UK is an NIHR non-commercial Partner and studies funded by Alzheimer’s Research UK grants are therefore eligible for consideration for NIHR Clinical Research Network (CRN) support. If the study involves the NHS or NHS patients, Alzheimer’s Research UK expects grant holders to apply where appropriate for consideration for NIHR CRN support and subsequent inclusion in the NIHR CRN Portfolio.If the study meets the CRN’s criteria for support, it will be added to the NIHR CRN Portfolio. Alzheimer’s Research UK then expects grant holders to (i) keep the study record on the Portfolio Database up to date and (ii) upload recruitment data into the Portfolio Database on a monthly basis.
Join Dementia Research
Are you looking for ways to boost your study recruitment? Do you want to see if a future study would be possible? ‘Join dementia research’ is a fantastic service developed by the NIHR in partnership with Alzheimer’s Research UK and Alzheimer’s Society, which allows the public to register their interest in getting involved in research studies. The aim of Join Dementia Research is to improve the timeliness of study recruitment for researchers, and provide a service to thousands of potential volunteers who want to be involved in research. Please visit the website to find out how to register your study.
For those planning research studies in care homes, please take a look at the NIHR toolkit for Enabling Research in Care Homes.
Dementias Platform UK
Dementias Platform UK (DPUK) is a multi-million pound public-private partnership, developed and led by the Medical Research Council. DPUK is creating an optimal environment for dementias research by aligning information from over 25 longitudinal cohort studies and enriching certain datasets. Researchers will have easier access to data to support their research, which will be retrieved via a single point. For more information please contact firstname.lastname@example.org
National Centre for the Replacement Refinement and Reduction of Animals in Research – the ARRIVE guidelines
The ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines have been developed by the NC3Rs and are intended to improve standards of reporting and ensure that the data from animal experiments can be fully evaluated and utilised. When planning animal studies, please take a look at guidelines from the NC3Rs for experimental design. Researchers using animals are expected to give appropriate consideration to the 3Rs (Replacement, Refinement and Reduction), make use of the ARRIVE guidelines when designing their experiments, and ensure that they report animal-based studies in accordance with the ARRIVE guidelines as far as possible, taking into account the specific editorial policies of the journal concerned.
To get more tips about implenting the 3Rs into your grant applications you can watch a video from our ‘Grant writing for success workshop’.
Dementia Research Funding Portal
The Dementia Research Funding Portal brings together funding opportunities from all the main UK research funders to provide a one stop shop for dementia researchers. The portal makes it easy for researchers to access the latest grant rounds, as well as news on relevant events, conferences and useful links.